Centre for Advanced Microbiology and Immunology in Veterinary Medicine (ADMIREVET)
The AdmireVet project is mainly focused on applied research based on shared projects with business partners. Due to its unique instrumentation, the newly established centre is comparable with leading workplaces in the world.
The main research carried out under the AdmireVet project is aimed at the development of live and inactivated veterinary vaccines, the study of host immune responses after vaccination, testing of biologically active drugs to enhance immunity, development of diagnostic kits for rapid detection of biological agents and chemical contaminants, and monitoring of causative agents of serious infectious diseases in farm animal herds in order to develop programmes for their prevention and control.
Besides organizing these activities, an equally important objective of the project is training the new generation of specialists in the given field of study who will be employable in the labour market in research, production and state administration in agriculture and veterinary medicine. Their training is carried out under doctoral programmes and internships in similar workplaces abroad.
The first results achieved at the AdmireVet Centre are already on the market
The development of diagnostic kits and vaccines for farm animals performed under the conditions of the project, are of major importance for the agricultural sector.Some diagnostic kits are already on the market, such as kits for the diagnostics of enzootic bovine leucosis, immunodiagnostics for detecting food chain contaminants, diagnostics of spring viraemia of carp, infectious pancreatic necrosis of salmonids and viral haemorrhagic septicaemia of fish, which is one of the economically most detrimental diseases in fish. Regarding the diagnostics of pig diseases, these are important for animal health protection against diseases (such as Aujeszky´s disease, and infections caused by the bacterium Haemophilus parasuis) and also for increasing the safety of pork-based foods. Meat and its products are potential sources of pathogens causing human infections, including e.g. Salmonellosis, hepatitis E and trichinosis. Some of these results have been protected by patent applications.
Diagnostic kits are manufactured in cooperation with companies, such as TestLine Clinical Diagnostics, s.r.o. Currently, two vaccines have been successfully registered: one against respiratory infections of cattle (put on the market by Bioveta, a.s. in cooperation with the VRI), and the other one for passive protection against the edematous disease of pigs.
Basic data on the project
Registration number of the project: CZ.1.05/2.1.00/01.0006
Project starting date: 1st December 2009
Project ending date: 31st December 2013
Monitoring end date: 31st December 2018
- Development of live, inactivated and subunit veterinary vaccines
- Study of the host immune response after vaccination
- Testing of therapeutics, adjuvants and other biologically active preparations
- Development of diagnostic kits for the detection of biological agents and chemical contaminants
- Monitoring of causative agents of serious infectious diseases in farm animal herds
Training of young scientists
The most crucial parts of the project
- Reconstruction of Building III at the VRI
- Reconstruction of experimental animal facilities No. 4 and 5
- Purchase of equipment for the AdmireVet project laboratories
- Training of the staff at leading institutions in the Czech Republic and abroad
Total budget for the project
Total expenditure: 365,263,120 CZK
Non-investment: 74,735,320 CZK
Investment: 290,527,800 CZK
|Total amount of funding:||365,263,120 CZK|
|From the European Union´s budget:||310,473,652 CZK||, which equals 85%|
|From the CR government´s budget:||54,789,468 CZK||, which equals 15%|
Project of the Operational Programme Research and Development for Innovation (2007 – 2013)
Development of research capacity of the AdmireVet Centre
Basic data on the project
Project starting date: 1 October 2015
Project ending date: 31 December 2015
Monitoring end date: 31 December 2020
The main aim of the project is the development of the AdmireVet Centre´s research infrastructure in the area of the following research programmes:
- Veterinary epidemiology and diagnostics
- Vaccines and prevention
These programmes of cooperative research are implemented together with partners from the application sphere and the development of the programmes contributes to the strengthening of the competitiveness within and outside the South Moravian Region.
The project is implemented in direct connection with the implementation of research activities "Identification of bacterial agents" and "Sorting of cell populations."
For the purposes of carrying out the activity "Identification of bacterial agents", a MALDI TOF/TOF Mass Spectrometer was acquired under the project. This instrument allows rapid and accurate identification of bacterial agents, including more complex organisms such as Mycobacteria, but also other harmful pathogens from risk groups 2 and especially 3 (BSL3). Besides the identification, the instrument will be used for advanced classification studies, epidemiological studies, typing of bacteria and the detection of strains resistant to antimicrobials.
The instrument will be used for the development of proteomic analyses, e.g. the identification of proteins and peptides. These analyses will be performed using protein digestion with subsequent detection by MALDI TOF/TOF or in combination with pre-separation by HPLC methods or gel electrophoresis. These techniques will be used e.g. for the identification of bacterial toxins, precise identification of which is currently very complicated. Furthermore, in the future, the device will be used for spatial localization of proteins and peptides by the MALDI imaging technique. The instrument will allow improvements in the methodological approach. It will also extend knowledge as planned for the implementation period of the existing activities of NPU I project, reg. No. LO1218, acronym OneHealth (“Epidemiology and pathogenesis of important veterinary diseases and zoonoses of bacterial origin” and “Development and application of methods for diagnosis of pathogens and contaminants of food chains and the environment”) and will also be used in dealing with new activities, especially in the field of antimicrobial resistance and food safety. The activity Identification of bacterial agents is linked to the research programme "Veterinary epidemiology and diagnostics".
For the purposes of the activity "Sorting of cell populations", a Flow cytometer providing cell sorting was acquired. This instrument is based on the method of flow cytometry, but also allows the real procurement of cells with certain characteristics – cell size vs. granularity; the presence of surface proteins or intracellular proteins. Thus defined and obtained cell populations will be used for subsequent laboratory analyses (e.g. molecular biology detection of expression of genes encoding relevant proteins and cell function assays) due to which it will be further possible to define their function and thus deduce their role and importance in the monitored processes – whether in immunopathogenesis of diseases under study or in immune responses to vaccines used.
The instrument will allow improvement in sophisticated analyses and in some cases even thei accomplishment during fulfilment of the existing activities of NPU I project, reg. No. LO1218, acronym OneHealth (Epidemiology and pathogenesis of important veterinary diseases and zoonoses). The activity "Sorting of cell populations" is connected to the research programme "Vaccines and prevention".
Key equipment for the project
- MALDI TOF/TOF Mass Spectrometer
- Flow cytometer for cell sorting
Total budget for the project
Total expenditure: 25,532,000 CZK
Non-investment: 32,000 CZK
Investment: 25,500,000 CZK
|Total support amount:||25,532,000 CZK|
|From the European Union´s budget:||21,702,200 CZK||, which equals 85%|
|ZFrom the CR government´s budget:||3,829,800 CZK||, which equals 15%|
Information regarding the entire operational programme and the situation around are published there.
AdmireVet project is part of this presentation.
The iDNES.cz news site published an article about the AdmireVet project entitled A new veterinary research centre was successful in scientific work (1st November 2013)
The iDNES.cz news site published an article about the AdmireVet project entitled The establishment of the advanced AdmireVet Centre opens a new phase of research (24th May 2013)
Novinky.cz on paratuberculosis and Crohn´s disease (19th May 2010)
EURO Weekly News about the AdmireVet project (19th April 2010)
Czech TV broadcast an interview on the AdmireVet project
On Monday 22 February 2010, Prof. Ivo Pavlík and Ing. Markéta Kabourková were interviewed by Mgr. Jiří Václavek on the programme entitled Milénium
9th December 2009
The AdmireVet project was established:Scientists in Brno will be developing vaccines for animals funded by an EU project
A significant investment in agricultural science and research, Ministry of Agriculture of the Czech Republic
Top vaccines for animals are being produced in Brno, Brněnský deník
The EU in Brussels made a significant investment in research and development to the VRI in Brno, Pressweb
EURO.cz (7th November 2009)
Billions from OP R&DI go to particular universities and research institutions (26th November 2009)
44 research tentacles
Mediafax, (27th November 2009)
Four research projects will receive over two billion Czech Crowns from the EU
The success of the scientists: They received 1.5 billion Czech Crowns (28th November 2009)
Information on EU funds and programmes
European Regional Development Fund
OP Research and Development for Innovations